Smoothness/Roughness of an ROI

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Smoothness/Roughness of an ROI

Liana
I have cell spheroids and I need to measure their surface smoothness. They
are 2D images and I'd like to draw an ROI around the border and measure how
smooth that ROI is. If anyone has any input that would be appreciated.

<http://imagej.1557.x6.nabble.com/file/n5013034/D6_6.jpg>
 vs
<http://imagej.1557.x6.nabble.com/file/n5013034/150326_D6_2.jpg>