post-doc/scientific programmer position available for ImageJ project

[Till Bretschneider-2]

Dear ImageJ users/developers,

 

There is a post-doc/scientific programmer position to be filled immediately in our recently established group at Warwick Systems Biology Centre (http://go.warwick.ac.uk/bretschneider).

It is embedded in the SABR project "Dynamics and functon of the NF-kB signaling system" led by David Rand, Warwick, and Mike White, Liverpool. Please find a summary of the project below.

 

The work will require somebody with strong programming skills and experience in image processing (ImageJ), preferably but not necessarily with a background in cell biology.

Based on different existing prototypes we will develop novel image analysis software to quantify the periodic shuttling of NF-kB in and out of the cell nucleus. There is a wide range of other possible applications so that the software is expected to have a high impact.

 

Please contact me for further information and pass this on to anybody who you think might be interested.

 

Best regards,

 

Till Bretschneider

 

 

Dynamics and functon of the NF-kB signaling system.
Grant from Systems Approaches to Biological Research (SABR) initiative, 2007. Joint bid led by Prof. M White (Liverpool) and Rand. Project co-directors Mike White and Rand will be assisted by a small management team.
Total grant funding: approx. £5.8m (100% FEC).
Warwick share: £931,771 (100% FEC), £745,416.81 (80% FEC)

Summary. We will develop an integrated systems biology programme to analyse the dynamic and physiological function of the NF-kappaB signalling system. We previously applied iterative real-time imaging and mathematical modelling approaches to show that the NF-kappaB system is oscillatory and uses delayed negative feedback to direct nuclear to cytoplasmic cycling of transcription factor(s) that regulate gene expression. Our recent work has made clear how little is currently understood about even the core parts of the NF-kappaB system and only included a small subset of the NF-?B proteins and feedback loops. We will develop and apply a set of quantitative experimental tools coupled to an intensive theoretical analysis to properly analyse the dynamic function of the system. A key question is how cells achieve appropriate cell fate decisions in response to time-varying signals. Our team includes the expertise to measure and simulate the important processes involved in the core NF-?B network and is supported by leading technology companies.. The experimental work (involving network perturbations) will integrate dynamic cell and single molecule imaging, quantitative proteomics (for measurement of absolute protein and phosphoprotein levels and rates of turnover), chromatin immunoprecipitation (ChIP) analysis (for the dynamics of NF-kappaB binding to target promoters) and RT-PCR and DNA microarray analysis (for measurement of  endogenous gene expression). The theoretical work will develop: 1) new data analysis tools to interpret and direct experimental strategy, 2) deterministic and 3) stochastic mathematical models of the system. The computer simulations will develop new experimentally testable hypotheses. Our goal is complete understanding of this complex and non-linear system. We will determine how the set of complex feedback loops controls NF-kappaB dynamics and controls downstream gene

 

Dr. Till Bretschneider
Assistant Professor
Warwick Systems Biology Centre
Coventry House
University of Warwick
Coventry CV4 7AL
United Kingdom

room: #344

Tel: [phone]
E-mail: [hidden email]
URL: http://go.warwick.ac.uk/bretschneider

Workshop "Cytoskeletal Patterns and Architectures", 12th to 14th May 2008: http://go.warwick.ac.uk/cytoskeleton2008