Re: Sickle Cell Anemia Detection

Posted by Daniel Hornung on Oct 22, 2009; 3:08pm
URL: http://imagej.273.s1.nabble.com/Sickle-Cell-Anemia-Detection-tp3690671p3690675.html

Benjamin Grant wrote:
> Hi all,
> I am trying to implement sickle cell anemia detection in imageJ. I don't
> need programming advice currently, but just method ideas. Sickle cells are
> jagged shaped compared to smooth, round normal cells. Any method available
> to detect these sharp edges? Any thoughts? Thanks a lot
> Ben

Hello Ben,

you could try to automatically segment the cells, fit an ellipse to the mask
(http://rsb.info.nih.gov/ij/developer/api/ij/process/EllipseFitter.html) and
compare the length (major axis) or circumference to the results you got from
your segmentation.  You could also try to fit curves (e.g. Bezier curves or a
spline) to the segmentation boundary and search for high local curvatures there.

These are just some ideas, I'm sure you'll find more yourself.
HTH, Daniel

--
Daniel Hornung

Biomedical Physics Group
Max-Planck-Institute for Dynamics and Self-Organization
Bunsenstr. 10
D-37073 Goettingen

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