Posted by
Barboriak, Daniel on
Nov 15, 2006; 2:42pm
URL: http://imagej.273.s1.nabble.com/time-domain-curve-fitter-tp3701002p3701004.html
Hi Simon,
We are fairly close to releasing a plugin that does some but probably not
all that you want. I'm assuming, perhaps incorrectly, that you are doing
T2-weighted dynamic susceptibility contrast MRI. Our plugin called DSCoMAn
(Dynamic Susceptibility Contrast MR Analysis) will be able to convert image
intensity DSC MRI data to delta R2 images. Because we are studying brain
tumors, we are analyzing the data using the Boxerman Weisskoff method. For
our inital release, users will also have the option of making crude maps of
rCBV and rMTT using the raw delta R2 images.
Here is the URL with a description:
http://dblab.duhs.duke.edu/modules/news/article.php?
com_mode=nest&com_order=1&storyid=14
This is (I hope) only a couple of weeks away.
ImageJ has it's own simplex gamma variate fitting routine (Analyze ...
Tools ... Curve Fitting). This could be adapted for your purposes,
although to be honest I am persuaded by the Li's argument (see
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?
db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=14684217&query_hl=14&itoo
l=pubmed_docsum ) that the formula would need to be recast or a local
density random walk distribution would be better to use. This will likely
be a future direction for our software.
Thanks,
--db
Daniel Barboriak, MD
Neuroradiology
Duke University Medical Center
On Tue, 14 Nov 2006 10:14:02 -0500, Simon Roussel <
[hidden email]>
wrote:
>Hi,
>ImageJ has got a curve fitter.
>I am looking for a "time-domain" or "z axis" image fitter.
>I would like to have for each pixel of a stack, a fit (actually
>gamma-variate) along the z axis. It could return a stack with the same z
>values, but where the pixels values would be predicted from the fit, or
>alternatively another stack with the coefficients of the fit.
>I would use that to analyse MRI data following first-pass in the brain of a
>contrast agent to derive cerebral blood volume and mean transit time.
>Does anyone know a plugin, macro which already does that or could be
adapted ?
>Thanks in advance,
>Cheers,
>Simon
>========================================================================